Copper(I)-catalyzed cycloaddition of 4-bromosydnones and alkynes for the regioselective synthesis of 1,4,5-trisubstituted pyrazoles.
Fiche publication
Date publication
janvier 2015
Journal
Organic letters
Auteurs
Membres identifiés du Cancéropôle Est :
Dr KOLODYCH Sergii
Tous les auteurs :
Decuypere E, Specklin S, Gabillet S, Audisio D, Liu H, Plougastel L, Kolodych S, Taran F
Lien Pubmed
Résumé
Copper-catalyzed cycloaddition of alkynes with 4-bromosydnones provides a convenient, mild, and regioselective method for the synthesis of a wide range of bromopyrazoles. The broad functional group tolerance of the cycloaddition reaction and further palladium-catalyzed cross-coupling reactions allowed the preparation of polyfunctionalized 1,4,5-pyrazoles that are otherwise difficult to obtain by conventional methods.
Mots clés
Alkynes, chemistry, Catalysis, Copper, chemistry, Cycloaddition Reaction, Molecular Structure, Pyrazoles, chemical synthesis, Stereoisomerism, Sydnones, chemistry
Référence
Org. Lett.. 2015 Jan;17(2):362-5