Stability and toxicity of ZnO quantum dots: interplay between nanoparticles and bacteria.
Fiche publication
Date publication
janvier 2015
Journal
Journal of hazardous materials
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHNEIDER Raphaël
Tous les auteurs :
Bellanger X, Billard P, Schneider R, Balan L, Merlin C
Lien Pubmed
Résumé
The toxicity of quantum dots (QDs) has been commonly attributed to the release of metal ions from the core as well as to the production of reactive oxygen species. However, the information related to the stability of the nanoparticles are relatively scarce although this parameter may strongly influence their toxicity. The stability of aminosilane-capped ZnO QDs, here used as model nanoparticles, was investigated by inductively coupled plasma-optical emission spectrometer (ICP-OES) and whole cell biosensors using a dialysis setup to separate the QDs from the leaked Zn(2+) ions. The integrity of the ZnO QDs appeared strongly affected by their dilution in aqueous medium, whereas the nanoparticles were slightly stabilized by bacteria. Our results demonstrate some inadequacy between the implementation and use of whole cell biosensors, and the monitoring of metal release from QDs.
Mots clés
Bacteria, drug effects, Biosensing Techniques, Hazardous Substances, toxicity, Quantum Dots, toxicity, Reactive Oxygen Species, metabolism, Zinc Oxide, toxicity
Référence
J. Hazard. Mater.. 2015 ;283:110-6