The role of ILC subsets in cancer.
Fiche publication
Date publication
octobre 2022
Journal
Seminars in immunology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BRUCHARD Mélanie
Tous les auteurs :
Bruchard M, Spits H
Lien Pubmed
Résumé
The family of innate lymphoid cells (ILCs) are composed of five canonical subsets, NK cells, ILC1, ILC2, ILC3 and Lymphoid tissue inducer cells. ILCs have important functions in early stages of immune response towards infectious agents. ILCs are highly plastic enabling rapid modification of their functions dependent on the type of microbe and tissue environment to optimally counter these microbes. Data that still accumulate in a rapid pace indicate that these cells are also involved in immunity against tumor cells. Paradoxically ILC subsets have been shown to have tumor suppressing and tumor promoting activities. In this brief review we provide a snapshot of our current knowledge of characteristics and functions of tumor infiltrating ILC subsets and speculate on how these cells can be harnessed to mediate anti-tumor immunity.
Mots clés
Cancer immunity, Innate Lymphoid Cells
Référence
Semin Immunol. 2022 10 25;61-64:101654