Human amniotic membrane application in oral surgery-An pilot study.
Fiche publication
Date publication
octobre 2022
Journal
Frontiers in bioengineering and biotechnology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr POUTHIER Fabienne, Dr GINDRAUX Florelle
Tous les auteurs :
Odet S, Solecki L, Meyer C, Weber E, Chatelain B, Euvrard E, Barrabé A, Gualdi T, Parmentier AL, Tatu L, Pouthier F, Louvrier A, Gindraux F
Lien Pubmed
Résumé
The purpose of this pilot porcine study was to explore and illustrate the surgical application of human amniotic membrane (hAM) in an model of medication-related osteonecrosis of the jaw (MRONJ). Five oral and maxillofacial surgeons participated to this study. MRONJ was simulated on porcine mandible specimens. hAM was applied using four different techniques: implantation with complete coverage, implantation with partial coverage, apposition and covering graft material. At the same time, the surgeons evaluated how well the hAM handled and its physical properties during the surgery. Surgeons found that hAM had suitable mechanical properties, as it was easy to detach from the support, handle, bind to the defect and bury. hAM was also found to be strong and stable. The "implantation with complete coverage" and "implantation with partial coverage" techniques were the preferred choices for the MRONJ indication. This study shows that hAM is a graft material with suitable properties for oral surgery. It is preferable to use it buried under the gingiva with sutures above it, which increases its stability. This technical note aims to educate surgeons and provide them with details about the handling of hAM in oral surgery. Two surgical techniques for hAM application in MRONJ were identified and illustrated. hAM handling and physical properties during surgery were reported.
Mots clés
amniotic membrane, ex vivo, oral mucosa, osteonecrosis of the jaw and illustrations, porcine jaw, xenograft
Référence
Front Bioeng Biotechnol. 2022 10 24;10:968346