Gingival fibroblasts protect against experimental abdominal aortic aneurysm development and rupture through tissue inhibitor of metalloproteinase-1 production.
Fiche publication
Date publication
septembre 2017
Journal
Cardiovascular research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr POTTEAUX Stéphane
Tous les auteurs :
Giraud A, Zeboudj L, Vandestienne M, Joffre J, Esposito B, Potteaux S, Vilar J, Cabuzu D, Kluwe J, Seguier S, Tedgui A, Mallat Z, Lafont A, Ait-Oufella H
Lien Pubmed
Résumé
Abdominal aortic aneurysm (AAA), frequently diagnosed in old patients, is characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated extracellular matrix destruction. Despite improvement in the understanding of the pathophysiology of aortic aneurysm, no pharmacological treatment is yet available to limit dilatation and/or rupture. We previously reported that human gingival fibroblasts (GFs) can reduce carotid artery dilatation in a rabbit model of elastase-induced aneurysm. Here, we sought to investigate the mechanisms of GF-mediated vascular protection in two different models of aortic aneurysm growth and rupture in mice.
Mots clés
Abdominal aortic aneurysm, Cell therapy, Gingival fibroblasts, Metalloproteases, Remodelling
Référence
Cardiovasc Res. 2017 09 1;113(11):1364-1375