Deletion of mu opioid receptors reduces palatable solution intake in a mouse model of binge eating.
Fiche publication
Date publication
avril 2020
Journal
Behavioural pharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEFORT Katia
Tous les auteurs :
Awad G, Roeckel LA, Massotte D, Olmstead MC, Befort K
Lien Pubmed
Résumé
Binge eating in humans is driven by hedonic properties of food, suggesting that brain reward systems may contribute to this behaviour. We examined the role of mu opioid receptors (MOP) in binge eating by examining sweet solution intake in mice with genetic deletion of the MOP. Wildtype and MOP knockout mice had 4 hours access to food in the home cage combined with limited (4 hours) access to sucrose (17.1% w/v) or saccharin (0.09% w/v), or continuous (24 hours) access to sucrose. Only limited access groups exhibited binge intake, measured as increased solution consumption during the first hour. Knockout mice consumed less solution and food during the first hour as well as less food each day compared with wildtype mice. Limited access groups consumed more food and gained more weight than continuous access groups, and the effect was magnified in saccharin-consuming mice. Indeed, the increased food consumption in animals given limited access to saccharin was so excessive that caloric intake of this group was significantly higher than either of the sucrose groups (limited or continuous access). Within this group, females consumed more food per bodyweight than males, highlighting important sex differences in feeding behaviours under restricted access schedules.
Mots clés
Animals, Binge-Eating Disorder, Body Weight, Bulimia, metabolism, Disease Models, Animal, Eating, psychology, Energy Intake, physiology, Feeding Behavior, physiology, Female, Food Preferences, physiology, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Opioid, mu, metabolism, Reward, Sucrose, metabolism
Référence
Behav Pharmacol. 2020 04;31(2&3):249-255