Impact of formulation design and lyophilisation on the physicochemical characteristics of finasteride nanosystems.
Fiche publication
Date publication
février 2023
Journal
Journal of microencapsulation
Auteurs
Membres identifiés du Cancéropôle Est :
Dr IDOUX-GILLET Ysia
Tous les auteurs :
Irfan MM, Shah SU, Shah KU, Anton N, Idoux-Gillet Y, Conzatti G, Shah KU, Perennes E, Vandamme T
Lien Pubmed
Résumé
The fundamental purpose of this study was to develop a stable lyophilised finasteride nanosystem (FNS-NS) for topical delivery. The FNS-NS was fabricated using an ultrasonication technique. The impact of two different cryoprotectants on the physicochemical characteristics of FNS-NS before and after lyophilisation was thoroughly investigated. The lyophilised FNS-NS had spherical shape with particle size lied between 188.6 nm ± 4.4 and 298.7 nm ± 4.7, low PDI values (0.26 ± 0.02 to 0.32 ± 0.02) and zeta potential ranging from -38.3 to +53.3 mV. The confocal laser microscopy depicted a comparatively higher cellular internalisation achieved for undecorated FNS-NS with respect to its chitosan-decorated counterpart. The lyophilised FNS-NS was stable for 90 days at proper storage conditions. The FNS-NS with 15% trehalose had appropriate physicochemical attributes that could be a promising carrier for topical delivery to treat androgenic alopecia.
Mots clés
Finasteride, cellular uptake, chitosan, lyophilisation, nanosystem
Référence
J Microencapsul. 2023 02 24;:1-18