Impact of prednisone in patients with repeated embryo implantation failures: Beneficial or deleterious?
Fiche publication
Date publication
juin 2018
Journal
Journal of reproductive immunology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BENSUSSAN Armand
Tous les auteurs :
Lédée N, Prat-Ellenberg L, Petitbarat M, Chevrier L, Simon C, Irani EE, Vitoux D, Bensussan A, Chaouat G
Lien Pubmed
Résumé
Corticotherapy is the leading medication worldwide for patients with history of repeated implantation failures (RIF) after IVF/ICSI. Nevertheless, we still do not know its local mechanism of action, hence its precise indication. Our objective is to document the impact of prednisone on the endometrial expression of immune biomarkers (CD56 cells count, IL-18/TWEAK, IL-15/Fn-14 mRNA ratio) at the time of uterine receptivity in a RIF population.
Mots clés
Corticoids, Endometrium, IVF/ICSI, Implantation failures, Uterine receptivity
Référence
J Reprod Immunol. 2018 06;127:11-15