Gut microbiota remodeling and intestinal adaptation to lipid malabsorption after enteroendocrine cell loss in adult mice.
Fiche publication
Date publication
février 2023
Journal
Cellular and molecular gastroenterology and hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DE ARCANGELIS Adèle, Dr GRADWOHL Gérard
Tous les auteurs :
Blot F, Marchix J, Ejarque M, Jimenez S, Meunier A, Keime C, Trottier C, Croyal M, Lapp C, Mahe MM, De Arcangelis A, Gradwohl G
Lien Pubmed
Résumé
Enteroendocrine cells (EECs) and their hormones are essential regulators of whole-body energy homeostasis. EECs sense luminal nutrients and microbial metabolites and subsequently secrete various hormones acting locally or at a distance. Impaired development of EECs during embryogenesis is life-threatening in newborn mice and humans due to compromised nutrient absorption. However, the physiological importance of the EEC system in adult mice has yet to be directedly studied. Herein, we aimed to determine the long-term consequences of a total loss of EECs in healthy adults on energy metabolism, intestinal transcriptome and microbiota.
Mots clés
Enteroendocrine cells, food efficiency, lipid absorption, microbiota
Référence
Cell Mol Gastroenterol Hepatol. 2023 02 27;: