Semi-automated segmentation methods of SSTR PET for dosimetry prediction in refractory meningioma patients treated by SSTR-targeted peptide receptor radionuclide therapy.
Fiche publication
Date publication
mai 2023
Journal
European radiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr KARCHER Gilles, Pr MARIE Pierre-Yves, Pr TAILLANDIER Luc, Pr VERGER Antoine
Tous les auteurs :
Boursier C, Zaragori T, Bros M, Bordonne M, Melki S, Taillandier L, Blonski M, Roch V, Marie PY, Karcher G, Imbert L, Verger A
Lien Pubmed
Résumé
Tumor dosimetry with somatostatin receptor-targeted peptide receptor radionuclide therapy (SSTR-targeted PRRT) by Lu-DOTATATE may contribute to improved treatment monitoring of refractory meningioma. Accurate dosimetry requires reliable and reproducible pretherapeutic PET tumor segmentation which is not currently available. This study aims to propose semi-automated segmentation methods to determine metabolic tumor volume with pretherapeutic Ga-DOTATOC PET and evaluate SUV-derived values as predictive factors for tumor-absorbed dose.
Mots clés
68Gallium-DOTA(0)-Tyr(3)-octreotide, Lutetium Lu 177 dotatate, Meningioma, Radiometry
Référence
Eur Radiol. 2023 05 6;: