Polyploid giant cancer cells, cytokines and cytomegalovirus in breast cancer progression.
Fiche publication
Date publication
juin 2023
Journal
Cancer cell international
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HERBEIN Georges
Tous les auteurs :
Haidar Ahmad S, El Baba R, Herbein G
Lien Pubmed
Résumé
Breast cancer is the most common cancer among women. Accumulated evidence over the past decades indicates a very high prevalence of human cytomegalovirus (HCMV) in breast cancer. High-risk HCMV strains possess a direct oncogenic effect displayed by cellular stress, polyploid giant cancer cells (PGCCs) generation, stemness, and epithelial-to-mesenchymal transition (EMT) leading to cancer of aggressive phenotype. Breast cancer development and progression have been regulated by several cytokines where the latter can promote cancer cell survival, help in tumor immune evasion, and initiate the EMT process, thereby resulting in invasion, angiogenesis, and breast cancer metastasis. In the present study, we screened cytokines expression in cytomegalovirus-transformed HMECs (CTH cells) cultures infected with HCMV high-risk strains namely, HCMV-DB and BL, as well as breast cancer biopsies, and analyzed the association between cytokines production, PGCCs count, and HCMV presence in vitro and in vivo.
Mots clés
Breast cancer biopsies, CTH cells, Cytokines, High-risk HCMV strains, Human cytomegalovirus, PGCCs
Référence
Cancer Cell Int. 2023 06 20;23(1):119