Impact of deep brain stimulation (DBS) on olfaction in Parkinson's disease: Clinical features and functional hypotheses.
Fiche publication
Date publication
juin 2023
Journal
Revue neurologique
Auteurs
Membres identifiés du Cancéropôle Est :
Pr JACQUOT Lionel
Tous les auteurs :
Brand G, Bontempi C, Jacquot L
Lien Pubmed
Résumé
Deep brain stimulation (DBS) is a surgical therapy typically applied in Parkinson's disease (PD). The efficacity of DBS on the control of motor symptoms in PD is well grounded while the efficacity on non-motor symptoms is more controversial, especially on olfactory disorders (ODs). The present review shows that DBS does not improve hyposmia but can affect positively identification/discrimination scores in PD. The functional hypotheses suggest complex mechanisms in terms of cerebral connectivity and neurogenesis process which could act indirectly on the olfactory bulb and olfactory pathways related to specific cognitive olfactory tasks. The functional hypotheses also suggest complex mechanisms of cholinergic neurotransmitter interactions involved in these pathways. Finally, the impact of DBS on general cognitive functions in PD could also be beneficial to identification/discrimination tasks in PD.
Mots clés
Deep brain stimulation, Olfactory bulb, Olfactory disorders, Parkinson's disease, Subthalamic nucleus
Référence
Rev Neurol (Paris). 2023 06 8;: