Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly.
Fiche publication
Date publication
septembre 2023
Journal
Cell death discovery
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DEMIDOV Oleg
Tous les auteurs :
Belotserkovskaya E, Golotin V, Uyanik B, Demidov ON
Lien Pubmed
Résumé
Progress in the development of new sequencing techniques with wider accessibility and higher sensitivity of the protocol of deciphering genome particularities led to the discovery of a new phenomenon - clonal haematopoiesis. It is characterized by the presence in the bloodstream of elderly people a minor clonal population of cells with mutations in certain genes, but without any sign of disease related to the hematopoietic system. Here we will review this recent advancement in the field of clonal haematopoiesis and how it may affect the disease's development in old age.
Référence
Cell Death Discov. 2023 09 19;9(1):345