Role of the interstitium during septic shock: a key to the understanding of fluid dynamics?
Fiche publication
Date publication
octobre 2023
Journal
Journal of intensive care
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BRASSART-PASCO Sylvie, Dr BREZILLON Stéphane, Dr FOURNEL Isabelle
Tous les auteurs :
Dargent A, Dumargne H, Labruyère M, Brezillon S, Brassart-Pasco S, Blot M, Charles PE, Fournel I, Quenot JP, Jacquier M
Lien Pubmed
Résumé
While not traditionally included in the conceptual understanding of circulation, the interstitium plays a critical role in maintaining fluid homeostasis. Fluid balance regulation is a critical aspect of septic shock, with a well-known association between fluid balance and outcome. The regulation of transcapillary flow is the first key to understand fluid homeostasis during sepsis.
Mots clés
Capillary leak, Extracellular matrix, Interstitium, Microcirculation, Septic shock
Référence
J Intensive Care. 2023 10 10;11(1):44