A Macrophages-Enriched Head and Neck Tumor Spheroid Model to Study Foslip Behavior in Tumor Microenvironment.

Fiche publication


Date publication

novembre 2023

Journal

International journal of nanomedicine

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BEZDETNAYA-BOLOTINE Lina, Dr LASSALLE Henri-Pierre


Tous les auteurs :
Francois A, Dirheimer L, Chateau A, Lassalle HP, Yakavets I, Bezdetnaya L

Résumé

The tumor microenvironment (TME) is composed of various stromal components, including immune cells such as tumor-associated macrophages (TAMs), which play a crucial role in cancer initiation and progression. TAMs can exhibit either a tumor-suppressive M1 or a tumor-promoting M2 phenotype. First, we aimed to develop a 3D human heterotypic model consisting of head and neck squamous cell carcinoma (HNSCC) cells and different subtypes of macrophages to replicate the interactions between immune cells and cancer cells. We further investigated the behavior of Foslip, a liposomal formulation of temoporfin, using a macrophage-enriched 3D model.

Mots clés

Foslip, head and neck cancer, macrophage polarization, photodynamic therapy, tumor spheroids

Référence

Int J Nanomedicine. 2023 11 9;18:6545-6562