[Radiation-induced bronchiolitis obliterans with organizing pneumonia].
Fiche publication
Date publication
avril 2017
Journal
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VIGNOT Stéphane
Tous les auteurs :
Ducray J, Vignot S, Lacout A, Pougnet I, Marcy PY, Chapellier C, Foray N, Creisson A, Thariat J
Lien Pubmed
Résumé
Bronchiolitis obliterans with organizing pneumonia is an inflammatory reaction that can occur as a consequence of various pulmonary affections. Radiotherapy is not the sole and systematic cause of bronchiolitis obliterans with organizing pneumonia. Radiation-induced should not be confused with post-radiation, dose-dependent, inflammatory pulmonary fibrosis, which is non-immunological and located within the irradiation field. The role of immunity, local inflammation and individual radiosensitivity in bronchiolitis obliterans with organizing pneumonia is not well defined. Bronchiolitis obliterans with organizing pneumonia represents 1% of irradiated patients with breast cancer. It results in fever (flu-like symptoms), a rather dry cough and dyspnea. In the post-radiation context, bronchiolitis obliterans with organizing pneumonia may be diagnosed several months and up to a year after breast irradiation. The treatment consists of prolonged steroids or immunosuppressants, which do not prevent chronicity in 15% of patients and death in up to 5% of cases, the remaining 80% of patients healing without sequelae.
Mots clés
BOOP, Breast cancer, Bronchiolite oblitérante avec organisation pneumonique, Bronchiolitis obliterans with organizing pneumonia, Cancer du sein, Corticostéroïdes, Radiation therapy, Radiothérapie, Steroid
Référence
Cancer Radiother. 2017 04;21(2):148-154