Reduction of Pro-inflammatory Markers in RAW264.7 Macrophages by Polyethylenimines.
Fiche publication
Date publication
février 2024
Journal
Macromolecular bioscience
Auteurs
Membres identifiés du Cancéropôle Est :
Dr KICHLER Antoine
Tous les auteurs :
Frisch E, Dussouillez C, McCartin C, Blumberger J, Humbert C, Lebeau L, Frisch B, Heurtault B, Kichler A, Fournel S
Lien Pubmed
Résumé
The physiological problem of chronic inflammation and its associated pathologies attract ongoing attention with regard to methods for their control. Current systemic pharmacological treatments present problematic side effects. Thus, the possibility of new anti-inflammatory compounds with differing mechanisms of action or biophysical properties is enticing. Cationic polymers, with their ability to act as carriers for other molecules or to form bio-compatible materials, present one such possibility. Although not well described, several polycations such as chitosan and polyarginine, have displayed anti-inflammatory properties. The present work shows the ubiquitous laboratory transfection reagent, polyethylenimine (PEI) and more specifically low molecular weight branched PEI as also possessing such properties. Using a RAW264.7 murine cell line macrophage as an inflammation model, it was found the B-PEI 700 Da as being capable of reducing the production of several pro-inflammatory molecules induced by the endotoxin lipopolysaccharide. Although further studies are required for elucidation of its mechanisms, the revelation that such a common lab reagent may present these effects has wide-ranging implications, as well as an abundance of possibilities. This article is protected by copyright. All rights reserved.
Mots clés
Anti-inflammatory properties, Lipopolysaccharide, cationic polymer, immune modulation, macrophages, polyethylenimine
Référence
Macromol Biosci. 2024 02 28;:e2300492