Reduced dopamine release in Dcc haploinsufficiency male mice abolishes the rewarding effects of cocaine but not those of morphine and ethanol.
Fiche publication
Date publication
mars 2023
Journal
Psychopharmacology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DARCQ Emmanuel
Tous les auteurs :
Darcq E, Nouel D, Hernandez G, Pokinko M, Ash P, Moquin L, Gratton A, Kieffer B, Flores C
Lien Pubmed
Résumé
The Netrin-1/DCC guidance cue pathway is critically involved in the adolescent organization of the mesocorticolimbic dopamine circuitry. Adult mice heterozygous for Dcc show reduced dopamine release in the nucleus accumbens in response to amphetamine and, in turn, blunted sensitivity to the rewarding effects of this drug.
Mots clés
DCC receptors, Guidance cues, In vivo microdialysis cocaine, Netrin-1, Place preference
Référence
Psychopharmacology (Berl). 2023 03;240(3):637-646