Photo-induced anticancer activity and singlet oxygen production of prodigiosenes.
Fiche publication
Date publication
mai 2018
Journal
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FIGLIOLA Carlotta
Tous les auteurs :
Savoie H, Figliola C, Marchal E, Crabbe BW, Hallett-Tapley GL, Boyle RW, Thompson A
Lien Pubmed
Résumé
The photo-induced cytotoxicity of prodigiosenes is reported. One prodigiosene represents a synthetic analogue of the natural product prodigiosin, and two are conjugated to molecules that target the estrogen receptor (ER). A comparison of incubation and irradiation frameworks for the three prodigiosenes is reported, with activity against ER- and ER+ lines explored. Furthermore, the ability of the three prodigiosenes to photosensitise the production of singlet oxygen is demonstrated, shedding mechanistic light onto possible photodynamic therapeutic effects of this class of tripyrroles.
Mots clés
Anti-Bacterial Agents, chemistry, Antineoplastic Agents, chemistry, Cell Line, Tumor, Cell Survival, drug effects, Dose-Response Relationship, Drug, Humans, Molecular Structure, Photochemical Processes, Photochemotherapy, Photosensitizing Agents, chemistry, Prodigiosin, chemistry, Receptors, Estrogen, antagonists & inhibitors, Singlet Oxygen, chemistry, Structure-Activity Relationship
Référence
Photochem Photobiol Sci. 2018 05 16;17(5):599-606