Radiotherapy associated with concurrent bevacizumab in patients with non-metastatic breast cancer.
Fiche publication
Date publication
décembre 2014
Journal
Breast (Edinburgh, Scotland)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PEIGNAUX Karine
Tous les auteurs :
Pernin V, Belin L, Cottu P, Bontemps P, Lemanski C, De La Lande B, Baumann P, Missohou F, Levy C, Peignaux K, Bougnoux P, Denis F, Bollet M, Dendale R, Vago NA, Campana F, Fourquet A, Kirova YM
Lien Pubmed
Résumé
The purpose of this multicenter prospective and descriptive study was to determine late toxicities and outcomes among patients with non-metastatic breast cancer receiving concurrent bevacizumab (BV) and radiation therapy (RT) in the clinical trials. Early and late toxicities were assessed and evaluation was available for 63 patients (pts) at 12 months. Acute radiation dermatitis was observed in 48 (76%): grade 1 for 27, grade 2 for 17 and grade 3 for 4 pts. Grade 2 acute oesophagitis was observed in one patient (2%). Little toxicity was described 1 year after the completion of RT: 7 pts (12%): grade 1-2 pain, 3 (5%) presented grade 1 fibrosis, and 2 pts (4%) - telangiectasia. One patient (2%) experienced grade 1 dyspnoea. Five grade 1-2 lymphoedema occurred. Only one patient experienced a LEVF value less than 50% one year after the end of RT. In conclusion, the concurrent BV with locoregional RT provides acceptable toxicities.
Mots clés
Adult, Aged, Angiogenesis Inhibitors, adverse effects, Antibodies, Monoclonal, Humanized, adverse effects, Bevacizumab, Breast Neoplasms, pathology, Carcinoma, Ductal, Breast, pathology, Carcinoma, Lobular, pathology, Chemoradiotherapy, Adjuvant, adverse effects, Dermatitis, etiology, Dyspnea, etiology, Esophagitis, etiology, Female, Fibrosis, Humans, Lymphedema, etiology, Middle Aged, Neoadjuvant Therapy, Prospective Studies, Radiation Injuries, etiology, Radiation-Sensitizing Agents, adverse effects, Skin, pathology, Telangiectasis, etiology
Référence
Breast. 2014 Dec;23(6):816-20