Targeting two radiation-induced immunosuppressive pathways to improve the efficacy of normofractionated radiation therapy in a preclinical colorectal cancer model.
Fiche publication
Date publication
mars 2024
Journal
International journal of radiation biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ADOTEVI Olivier, Pr GHIRINGHELLI François, Dr MIRJOLET Céline, Pr TRUC Gilles, Dr LIMAGNE Emeric, Dr BOUSTANI Jihane
Tous les auteurs :
Boustani J, Lecoester B, Baude J, Latour C, Limagne E, Ladjohoulou R, Morgand V, Froidurot L, Ghiringhelli F, Truc G, Adotévi O, Mirjolet C
Lien Pubmed
Résumé
We have previously demonstrated in a murine colorectal cancer model that normofractionated RT (normoRT: 18 × 2 Gy) induced MDSC infiltration and PD-L1 expression, while hypofractionated RT (hypoRT: 3 × 8 Gy) induced Treg. Here, we wanted to assess whether the association of normoRT with treatments that target two radiation-induced immunosuppressive pathways (MDSC and PD-L1) could improve tumor control.
Mots clés
Radiation therapy, fractionation, immunosuppressive pathways, immunotherapy, treatment combination
Référence
Int J Radiat Biol. 2024 03 20;:1-10