Hypercaloric low-carbohydrate high-fat diet protects against the development of nonalcoholic fatty liver disease in obese mice in contrast to isocaloric Western diet.
Fiche publication
Date publication
mars 2024
Journal
Frontiers in nutrition
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GENY Bernard, Dr MALLARD Joris
Tous les auteurs :
Charlot A, Bringolf A, Mallard J, Charles AL, Niederhoffer N, Duteil D, Pagano AF, Geny B, Zoll J
Lien Pubmed
Résumé
Obesity and metabolic complications, such as type 2 diabetes and nonalcoholic fatty liver disease (NAFLD), are one of the greatest public health challenges of the 21st century. The major role of high sugar and carbohydrate consumption rather than caloric intake in obesity and NAFLD pathophysiology remains a subject of debate. A low-carbohydrate but high-fat diet (LCHFD) has shown promising results in obesity management, but its effects in preventing NAFLD need to be detailed. This study aims to compare the effects of a LCHFD with a high-fat high-sugar obesogenic Western diet (WD) on the progression of obesity, type 2 diabetes, and nonalcoholic fatty liver disease.
Mots clés
Western diet, insulin, low-carbohydrate diet, non-alcoholic fatty liver disease, obesity
Référence
Front Nutr. 2024 03 20;11:1366883