Development and evaluation of a pH-responsive Mimosa pudica seed mucilage/β- cyclodextrin-co-poly(methacrylate) hydrogel for controlled drug delivery: In vitro and in vivo assessment.

Fiche publication


Date publication

avril 2024

Journal

International journal of biological macromolecules

Auteurs

Membres identifiés du Cancéropôle Est :
Dr ERNST Barbara


Tous les auteurs :
Yasmin T, Mahmood A, Farooq M, Sarfraz RM, Boublia A, Rehman U, Ashraf MU, Bhutto JK, Ernst B, Albrahim M, Elboughdiri N, Yadav KK, Alreshidi MA, Ijaz H, Benguerba Y

Résumé

In this comprehensive investigation, a novel pH-responsive hydrogel system comprising mimosa seed mucilage (MSM), β-cyclodextrin (β-CD), and methacrylic acid (MAA) was developed via free radical polymerization technique to promote controlled drug delivery. The hydrogel synthesis involved strategic variations in polymer, monomer, and crosslinker content in fine-tuning its drug-release properties. The resultant hydrogel exhibited remarkable pH sensitivity, selectively liberating the model drug (Capecitabine = CAP) under basic conditions while significantly reducing release in an acidic environment. Morphological, thermal, and structural analyses proved that CAP has a porous texture, high stability, and an amorphous nature. In vitro drug release experiments showcased a sustained and controlled release profile. Optimum release (85.33 %) results were recorded over 24 h at pH 7.4 in the case of MMB9. Pharmacokinetic evaluation in healthy male rabbits confirmed bioavailability enhancement and sustained release capabilities. Furthermore, rigorous toxicity evaluations and histopathological analyses ensured the safety and biocompatibility of the hydrogel. This pH-triggered drug delivery system can be a promising carrier system for drugs involving frequent administrations.

Mots clés

Capecitabine, Hydrogels, Mimosa pudica seed mucilage, Pharmacokinetic evaluation, β-CD

Référence

Int J Biol Macromol. 2024 04 23;:131832