Anti-parietal cell autoimmunity is associated with an accelerated decline of lung function in IPF patients.
Fiche publication
Date publication
février 2018
Journal
Respiratory medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BELTRAMO Guillaume
Tous les auteurs :
Beltramo G, Thabut G, Peron N, Nicaise P, Cazes A, Debray MP, Joannes A, Castier Y, Mailleux AA, Frija J, Pradère P, Justet A, Borie R, Dombret MC, Taille C, Aubier M, Crestani B
Lien Pubmed
Résumé
Autoantibodies against lung epithelial antigens are often detected in patients with Idiopathic Pulmonary Fibrosis (IPF). Anti-Parietal Cell Antibodies (APCA) target the H+/K+ATPase (proton pump). APCA prevalence and lung H+/K+ATPase expression was never studied in IPF patients.
Mots clés
Autoimmunity, Hydrogen / potassium ATPase, Idiopathic pulmonary fibrosis, Proton pump
Référence
Respir Med. 2018 02;135:15-21