Subphthalocyanines: addressing water-solubility, nano-encapsulation, and activation for optical imaging of B16 melanoma cells.
Fiche publication
Date publication
novembre 2014
Journal
Chemical communications (Cambridge, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DECREAU Richard, Pr PERRIER-CORNET Jean-Marie
Tous les auteurs :
Bernhard Y, Winckler P, Chassagnon R, Richard P, Gigot É, Perrier-Cornet JM, Decréau RA
Lien Pubmed
Résumé
Water-soluble disulfonato-subphthalocyanines (SubPcs) or hydrophobic nano-encapsulated SubPcs are efficient probes for the fluorescence imaging of cells. 20 nm large liposomes (TEM and DLS) incorporated about 13% SubPc. Moreover, some of these fluorophores were found to be pH activatable.
Mots clés
Animals, Crystallography, X-Ray, Fluorescent Dyes, chemical synthesis, Hydrogen-Ion Concentration, Indoles, chemical synthesis, Liposomes, chemistry, Melanoma, Experimental, pathology, Mice, Models, Molecular, Molecular Imaging, Molecular Structure, Nanostructures, chemistry, Solubility, Water, chemistry
Référence
Chem. Commun. (Camb.). 2014 Nov 21;50(90):13975-8