From the design of innovative Ti-Pt heterometallic complexes to the development of highly anti-proliferative water-soluble cationic titanocenes.
Fiche publication
Date publication
mai 2024
Journal
Chembiochem : a European journal of chemical biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BETTAIEB Ali, Dr DUBREZ Laurence, Pr PAUL Catherine
Tous les auteurs :
Trommenschlager A, Mabrouk N, Racoeur C, Godard A, Balan C, Dubrez L, Bettaieb A, Husson J, Le Gendre P, Paul C, Bodio E
Lien Pubmed
Résumé
Two innovative early/late Ti-Pt-heterobimetallic complexes were synthesized, characterized, and screened in cell-based assays using several human (SW480 and MDA-MB-231) and murine cancer cell lines (CT26 and EMT6) as well as a non-cancerous cell line (HMEC). The combination of the two metals - titanium(IV) and platinum (IV) - in a single molecule led to a synergistic biological activity (higher anti-proliferative properties than a mixture of each of the corresponding monometallic complexes). This study also investigated the benefits of associating a metal-free terpyridine moiety (with intrinsic biological activity) with a water-soluble titanocene fragment. The present work reveals that these combinations results in water-soluble titanocene compounds displaying an anti-proliferative activity down to the submicromolar level. One of these complexes induced an antitumor effect in vivo in CT26 tumor bearing BALB/C mice. The terpyridine moiety was also used to track the complex in vitro by multiphoton microscopy imaging.
Mots clés
Platinum complex, Titanium complex, bimetallic complex, terpyridine, water-soluble titanocene
Référence
Chembiochem. 2024 05 15;:e202400099