Identification of endophenotypes supporting outcome prediction in hemodialysis patients based on mechanistic markers of statin treatment.
Fiche publication
Date publication
mai 2024
Journal
Heliyon
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ROSSIGNOL Patrick
Tous les auteurs :
Leierer J, Salib M, Evgeniou M, Rossignol P, Massy ZA, Kratochwill K, Mayer G, Fellström B, Girerd N, Zannad F, Perco P
Lien Pubmed
Résumé
Statins are widely used to reduce the risk of cardiovascular disease (CVD). Patients with end-stage renal disease (ESRD) on hemodialysis have significantly increased risk of developing CVD. Statin treatment in these patients however did not show a statistically significant benefit in large trials on a patient cohort level.
Mots clés
AURORA cohort, Cardiovascular risk, Cox proportional hazards regression models, Gene expression profiling, Hemodialysis, Patient stratification, Predictive biomarkers, Statins
Référence
Heliyon. 2024 05 15;10(9):e30709