Study protocol: the biologics in severe chronic rhinosinusitis with nasal polyps survey.
Fiche publication
Date publication
mai 2024
Journal
BMJ open
Auteurs
Membres identifiés du Cancéropôle Est :
Pr JANKOWSKI Roger
Tous les auteurs :
Favier V, Daveau C, Carsuzaa F, Fieux M, Vandersteen C, Castillo L, Papon JF, de Gabory L, Saroul N, Verillaud B, Rumeau C, Jankowski R, Michel J, de Bonnecaze G, Lecanu JB, Coste A, Béquignon E, Malard O, Mortuaire G
Lien Pubmed
Résumé
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a frequent condition affecting approximately 2% of the population. Medical treatment consists long-term use of intranasal corticosteroids and short-term use of oral corticosteroids, in adjunct with saline solution rinses. Surgical management is proposed in patients who failed after medical treatment. In France, two biologics are reimbursed in case of severe uncontrolled CRSwNP despite medical treatment and endoscopic sinus surgery. Waiting for head-to-head biologics comparison, studies should report the efficacy and safety of biologics in large real-life cohorts. This study protocol describes the aims and methods of a prospective, observational, national, multicentric cohort of patients with CRSwNP treated with biologics.
Mots clés
Adult otolaryngology, Asthma, Endoscopic surgery, IMMUNOLOGY
Référence
BMJ Open. 2024 05 15;14(5):e083112