Hypertriglyceridemia Results From an Impaired Catabolism of Triglyceride-Rich Lipoproteins in -Related Lipodystrophy.
Fiche publication
Date publication
juin 2024
Journal
Arteriosclerosis, thrombosis, and vascular biology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DUVILLARD Laurence, Pr VERGES Bruno
Tous les auteurs :
Vergès B, Vantyghem MC, Reznik Y, Duvillard L, Rouland A, Capel E, Vigouroux C
Lien Pubmed
Résumé
Pathogenic variants in -encoding PLIN1 (perilipin-1) are responsible for an autosomal dominant form of familial partial lipodystrophy (FPL) associated with severe insulin resistance, hepatic steatosis, and important hypertriglyceridemia. This study aims to decipher the mechanisms of hypertriglyceridemia associated with -related FPL.
Mots clés
kinetics, lipodystrophy, lipoprotein lipase, perilipin-1, triglycerides
Référence
Arterioscler Thromb Vasc Biol. 2024 06 20;: