Cellular Transformation by Human Cytomegalovirus.
Fiche publication
Date publication
mai 2024
Journal
Cancers
Lien Pubmed
Résumé
Epstein-Barr virus (EBV), Kaposi sarcoma human virus (KSHV), human papillomavirus (HPV), hepatitis B and C viruses (HBV, HCV), human T-lymphotropic virus-1 (HTLV-1), and Merkel cell polyomavirus (MCPyV) are the seven human oncoviruses reported so far. While traditionally viewed as a benign virus causing mild symptoms in healthy individuals, human cytomegalovirus (HCMV) has been recently implicated in the pathogenesis of various cancers, spanning a wide range of tissue types and malignancies. This perspective article defines the biological criteria that characterize the oncogenic role of HCMV and based on new findings underlines a critical role for HCMV in cellular transformation and modeling the tumor microenvironment as already reported for the other human oncoviruses.
Mots clés
HCMV, PGCCs, cytomegalovirus, hallmarks of cancer, high-risk HCMV, oncogenesis, oncomodulation, oncoviruses
Référence
Cancers (Basel). 2024 05 22;16(11):