Targeting of 3D oral cancer spheroids by αVβ6 integrin using near-infrared peptide-conjugated IRDye 680.
Fiche publication
Date publication
juin 2024
Journal
Cancer cell international
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BEZDETNAYA-BOLOTINE Lina, Pr MARCHAL Frédéric, Dr CORTESE Sophie
Tous les auteurs :
Dirheimer L, Pons T, François A, Lamy L, Cortese S, Marchal F, Bezdetnaya L
Lien Pubmed
Résumé
In the treatment of oral cavity cancer, margin status is one of the most critical prognostic factors. Positive margins are associated with higher local recurrence and lower survival rates. Therefore, the universal goal of oral surgical oncology is to achieve microscopically clear margins. Near-infrared fluorescence guided surgery (FGS) could improve surgical resection using fluorescent probes. αVβ6 integrin has shown great potential for cancer targeting due to its overexpression in oral cancers. Red fluorescent contrast agent IRDye 680 coupled with anti-αVβ6 peptide (IRDye-A20) represents an asset to improve FGS of oral cancer. This study investigates the potential of IRDye-A20 as a selective imaging agent in 3D three-dimensional tongue cancer cells.
Mots clés
Fluorescence imaging, Head and neck cancer, IRDye, Near Infrared fluorescence (NIR), Oral cancer, Spheroid, Tongue cancer, αVβ6 integrin
Référence
Cancer Cell Int. 2024 06 29;24(1):228