CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival.
Fiche publication
Date publication
juin 2023
Journal
Gut
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MARTEYN Benoît
Tous les auteurs :
Danne C, Michaudel C, Skerniskyte J, Planchais J, Magniez A, Agus A, Michel ML, Lamas B, Da Costa G, Spatz M, Oeuvray C, Galbert C, Poirier M, Wang Y, Lapière A, Rolhion N, Ledent T, Pionneau C, Chardonnet S, Bellvert F, Cahoreau E, Rocher A, Arguello RR, Peyssonnaux C, Louis S, Richard ML, Langella P, El-Benna J, Marteyn B, Sokol H
Lien Pubmed
Résumé
Inflammatory bowel disease (IBD) results from a combination of genetic predisposition, dysbiosis of the gut microbiota and environmental factors, leading to alterations in the gastrointestinal immune response and chronic inflammation. Caspase recruitment domain 9 (), one of the IBD susceptibility genes, has been shown to protect against intestinal inflammation and fungal infection. However, the cell types and mechanisms involved in the CARD9 protective role against inflammation remain unknown.
Mots clés
APOPTOSIS, GASTROINTESTINAL IMMUNE RESPONSE, GUT INFLAMMATION, IBD, IBD - GENETICS
Référence
Gut. 2023 06;72(6):1081-1092