Virotherapy of digestive tumors with rodent parvovirus: overview and perspectives.
Fiche publication
Date publication
mars 2016
Journal
Expert opinion on biological therapy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr AKLADIOS Chérif
Tous les auteurs :
Akladios C, Aprahamian M
Lien Pubmed
Résumé
Toolan's H-1 parvovirus (H-1PV) exerts a cytotoxic/oncolytic effect, predominantly mediated by its non-structural protein (NS1). This rat parvovirus is harmless, unlike other parvoviruses, and its antitumor potential may be useful to clinicians as its oncolytic action appears to be true in numerous non-digestive and digestive cancers.
Mots clés
Cancer virotherapy, Glioma, Oncolytic virus, Pancreatic ductal adenocarcinoma, Parvoviridae, Toolan’s H-1 parvovirus
Référence
Expert Opin Biol Ther. 2016 03 28;16(5):645-53