Cutibacterium acnes biofilm formation is influenced by bone microenvironment, implant surfaces and bacterial internalization.
Fiche publication
Date publication
juillet 2024
Journal
BMC microbiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie, Dr VELARD Frédéric
Tous les auteurs :
Varin-Simon J, Colin M, Velard F, Tang-Fichaux M, Ohl X, Mongaret C, Gangloff SC, Reffuveille F
Lien Pubmed
Résumé
The bacterial persistence, responsible for therapeutic failures, can arise from the biofilm formation, which possesses a high tolerance to antibiotics. This threat often occurs when a bone and joint infection is diagnosed after a prosthesis implantation. Understanding the biofilm mechanism is pivotal to enhance prosthesis joint infection (PJI) treatment and prevention. However, little is known on the characteristics of Cutibacterium acnes biofilm formation, whereas this species is frequently involved in prosthesis infections.
Mots clés
Cutibacterium acnes, Biofilm matrix, Internalization, Prosthesis joint infection
Référence
BMC Microbiol. 2024 07 20;24(1):270