Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice.
Fiche publication
Date publication
juillet 2024
Journal
Molecular metabolism
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PFRIEGER Frank
Tous les auteurs :
Duquenne M, Deligia E, Folgueira C, Bourouh C, Caron E, Pfrieger F, Schwaninger M, Nogueiras R, Annicotte JS, Imbernon M, Prévot V
Lien Pubmed
Résumé
In Western society, high-caloric diets rich in fats and sugars have fueled the obesity epidemic and its related disorders. Disruption of the body-brain communication, crucial for maintaining glucose and energy homeostasis, arises from both obesogenic and genetic factors, leading to metabolic disorders. Here, we investigate the role of hypothalamic tanycyte shuttles between the pituitary portal blood and the third ventricle cerebrospinal fluid in regulating energy balance.
Mots clés
Blood-cerebrospinal fluid barrier, Blood–brain barrier, Hypothalamus, Normal-weight central obesity, Tanycytes, Transports
Référence
Mol Metab. 2024 07 22;:101996