HLA-lacking clones in aplastic anaemia: Adaptive or maladaptive?
Fiche publication
Date publication
août 2024
Journal
British journal of haematology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PAGLIUCA Simona
Tous les auteurs :
Gurnari C, Lima ACM, Pagliuca S
Lien Pubmed
Résumé
HLA loss represents the result of immune forces shaping bone marrow clonal dynamics in immune aplastic anaemia. Human leukocyte antigen (HLA)-deficient clones may rescue haematopoiesis by evading immune attacks, potentially guiding treatment strategies. Commentary on: Zaimoku et al. Haematopoietic regeneration by HLA-A*0206-deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19712.
Mots clés
aplastic anaemia, clonal haematopoiesis, haematopoietic stem cells, immune suppressive treatment
Référence
Br J Haematol. 2024 08 26;: