Refining criteria for a neurodevelopmental sub-phenotype of bipolar disorders: a FondaMental Advanced Centers of Expertise for Bipolar Disorders study.
Fiche publication
Date publication
octobre 2024
Journal
Biological psychiatry
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HAFFEN Emmanuel
Tous les auteurs :
Lefrere A, Godin O, Jamain S, Dansou Y, Samalin L, Alda M, Aouizerate B, Aubin V, Rey R, Contu M, Courtet P, Dubertret C, Haffen E, Januel D, Leboyer M, Llorca PM, Marlinge E, Manchia M, Neilson S, Olié E, Paribello P, Pinna M, Polosan M, Roux P, Schwan R, Tondo L, Walter M, Tzavara E, Auzias G, Deruelle C, Etain B, Belzeaux R
Lien Pubmed
Résumé
Bipolar disorder (BD) is a complex and heterogeneous psychiatric disorder. Neurodevelopmental factors were suggested to contribute to the etiology of BD, yet a specific neurodevelopmental phenotype of the disorder remains unidentified. Our objective was to define and characterize a neurodevelopmental phenotype (NDP) in BD and validate its associations with clinical outcomes, polygenic risk scores (PGS), and treatment responses.
Mots clés
Neurodevelopment, bipolar disorder, genomics, lithium response, neurological soft sign, stratification
Référence
Biol Psychiatry. 2024 10 10;: