Keeping them all together: β-propeller domains in histone methyltransferase complexes.
Fiche publication
Date publication
octobre 2014
Journal
Journal of molecular biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BERGAMIN Elisa
Tous les auteurs :
Bergamin E, Blais A, Couture JF
Lien Pubmed
Résumé
Histone methyltransferases (HKMTs) residing in multi-subunit protein complexes frequently require the presence of β-propeller proteins to achieve their biological functions. Recent biochemical studies have highlighted the functional diversity of these scaffolding proteins in maintaining the integrity of the complexes, allosterically regulating HKMT enzymatic activity and acting as "histone tethering devices" to facilitate the interaction between HKMTs and their substrates. Structural studies have revealed that, while β-propeller domain proteins share structural similarity, they employ divergent mechanisms to achieve their functions. This review focuses on the progress made in the last decade to identify the biochemical determinants underlying the functions of these important proteins.
Mots clés
WD40 domain, chromatin biology, epigenetics, histone, β-propeller
Référence
J. Mol. Biol.. 2014 Oct 9;426(20):3363-75