Detection of Borrelia burgdorferi sensu lato by proteomics: a complementary diagnosis tool on erythema migrans biopsies.
Fiche publication
Date publication
octobre 2024
Journal
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Auteurs
Membres identifiés du Cancéropôle Est :
Pr LIPSKER Dan, Pr SAULEAU Erik-André, Pr MUTTER Didier
Tous les auteurs :
Cantero P, Ehret-Sabatier L, Lenormand C, Hansmann Y, Sauleau E, Zilliox L, Westermann B, Jaulhac B, Mutter D, Barthel C, Perdu-Alloy P, Martinot M, Lipsker D, Boulanger N
Lien Pubmed
Résumé
We have developed targeted proteomics in the context of Lyme borreliosis as a new direct diagnostic tool for detecting Borrelia proteins in the skin of patients with erythema migrans. If satisfactory, this proteomic technique could be used in addition to culture and/or PCR for disseminated infections, where Borrelia detection is essential to demonstrate active infection. In these infections, diagnosis is indirect and relies mainly on serology.
Mots clés
Borrelia burgdorferisensu lato, Lyme borreliosis, erythema migrans, proteomics, skin diagnosis
Référence
Clin Microbiol Infect. 2024 10 23;: