Characterization of focal pancreatic lesions using normalized apparent diffusion coefficient at 1.5-Tesla: preliminary experience.
Fiche publication
Date publication
juin 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HOEFFEL Christine
Tous les auteurs :
Barral M, Sebbag-Sfez D, Hoeffel C, Chaput U, Dohan A, Eveno C, Boudiaf M, Soyer P
Lien Pubmed
Résumé
PURPOSE: To compare the capabilities of apparent diffusion coefficient (ADC) and normalized ADC using the pancreatic parenchyma as reference organ in the characterization of focal pancreatic lesions. PATIENTS AND METHODS: Thirty-six patients with focal pancreatic lesions (malignant, n=18; benign tumors, n=10; focal pancreatitis, n=8) underwent diffusion-weighted MR imaging (DWI) at 1.5-Tesla using 3 b values (b=0, 400, 800 s/mm(2)). Lesion ADC and normalized lesion ADC (defined as the ratio of lesion ADC to apparently normal adjacent pancreas) were compared between lesion types using nonparametric tests. RESULTS: Significant differences in ADC values were found between malignant (1.150 x 10(-3)mm(2)/s) and benign tumors (2.493 x 10(-3)mm(2)/s) (P=0.004) and between benign tumors and mass-forming pancreatitis (1.160 x 10(-3)mm(2)/s) (P=0.0005) but not between malignant tumors and mass-forming pancreatitis (P=0.1092). Using normalized ADC, significant differences were found between malignant tumors (0.933 x 10(-3)mm(2)/s), benign tumors (1.807 x 10(-3)mm(2)/s) and mass-forming pancreatitis (0.839 x 10(-3)mm(2)/s) (P
Référence
Diagn Interv Imaging. 2013 Jun;94(6):619-27