Structure and cytotoxicity of steroidal glycosides from Allium schoenoprasum.
Fiche publication
Date publication
avril 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DUCHAMP Olivier
Tous les auteurs :
Timite G, Mitaine-Offer AC, Miyamoto T, Tanaka C, Mirjolet JF, Duchamp O, Lacaille-Dubois MA
Lien Pubmed
Résumé
A phytochemical analysis of the whole plant of Allium schoenoprasum, has led to the isolation of four spirostane-type glycosides (1-4), and four known steroidal saponins. Their structures were elucidated mainly by 2D NMR spectroscopic analysis and mass spectrometry as (20S,25S)-spirost-5-en-3beta,12beta,21-triol 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside (1), (20S,25S)-spirost-5-en-3beta,11alpha,21-triol 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside (2), laxogenin 3-O-alpha-L-rhamnopyranosyl-(1-->2)-[beta-D-glucopyranosyl-(1-->4)]-beta-D-glucop yranoside (3), and (25R)-5alpha-spirostan-3beta,11alpha-diol 3-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->4)]-beta-D-galactop yranoside (4). Four of the isolated compounds were tested for cytotoxic activity against the HCT 116 and HT-29 human colon cancer cell lines.
Référence
Phytochemistry. 2013 Apr;88:61-6