Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry.
Fiche publication
Date publication
juillet 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Dr FROCHOT Céline, Dr VANDERESSE Régis
Tous les auteurs :
Acherar S, Colombeau L, Frochot C, Vanderesse R
Lien Pubmed
Résumé
The review aims at being a summary of the use of copper-catalyzed azide-alkyne cycloaddition (CuAAC) in the synthesis of porphyrin, chlorin and phthalocyanine derivatives for different types of therapeutic applications. The click reaction is a powerful and versatile tool assisting scientists in the synthesis of various symmetrically and asymmetrically substituted tetrapyrrolic derivatives. For example, click chemistry is largely used for the elaboration of photosensitizer conjugates for photodynamic therapy applications. Some of other biological applications are also described.
Référence
Curr Med Chem. 2015 Jul 16.