Comparison of diagnostic performances of 18F-Fluoride PET with and without fused CT in the search for bone metastases.
Fiche publication
Date publication
février 2013
Auteurs
Membres identifiés du Cancéropôle Est :
Dr EYMARD Jean-Christophe, Pr PAPATHANASSIOU Dimitri, Dr PREVOST Alain, Dr JOUANNAUD Christelle
Tous les auteurs :
Moini S, Papathanassiou D, Bruna-Muraille C, Bouharati-Moussa K, Eymard JC, Savoye AM, Jouannaud C, Prevost A, Cure H, Liehn JC
Lien Pubmed
Résumé
Introduction.- Performing a CT acquisition along with a 18F-Fluoride PET study increases the effective dose delivered to the patient. We evaluated its value in the diagnosis of bone metastases. Material and methods.- Three observers retrospectively analyzed 18F-Fluoride PET images (non-attenuation corrected) without CT and attenuation corrected images fused with CT in 50 patients with a cancer. The skeleton was divided into 17 areas. A score of malignancy from 1 to 5 was attributed to each area. An area-based analysis was done as well as a patient-based analysis. For the latter, the score of the area with the highest score was given to each patient. Clinical follow-up of at least 6 months, pathology or other imaging procedures served as gold standard. Results.- For the three observers, the areas under the ROC curve of the area-based analysis were respectively 0.79, 0.97 and 0.70 without CT and 0.98, 0.98 and 0.96 with CT. The differences were significant (P
Référence
Med Nucl-imag Fonct Metab. 2013 Feb;37(2):19-25.