Perspective of the NEMOSIS platform in the context of dose reduction in imaging.
Fiche publication
Date publication
octobre 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GSCHWIND Régine, Dr HENRIET Julien
Tous les auteurs :
Laurent R, Gschwind R, Salomon M, Henriet J, Makovicka L
Lien Pubmed
Résumé
Perspective of the NEMOSIS platform in the context of dose reduction in imaging. Motion acquisition is frequently performed to improve the treatment ballistics of external radiation therapy. Nevertheless, this acquisition is an additional source of radiation exposure for the patient. The development of the numerical simulation platform NEMOSIS (NEural NEtwork MOtion SImulation System) offers new perspectives for the dose optimization in imaging. It allows one to generate a localized and customized lung motion using a 3D model of the patient. For 3 patients, 5 to 6 anatomic points were simulated and compared with the points plotted by the radiation therapist. In the worst case, the results show an average accuracy of 3 mm for all the points of a patient, at every phase, with an expanded uncertainty of plotting equal to 1.5 mm (confidence interval of 95%) and a maximum uncertainty of 6.53 mm over one phase. Another study comparing the GTV (Gross Tumor Volume) of a radiation therapist and that computed by NEMOSIS was also carried out. A Dice index stating a minimum correspondence of 0.80 was computed between these two types of volumes. These results make NEMOSIS a very promising tool as an alternative solution to irradiation imaging.
Référence
. 2012 Oct-dec;47(4):599-617.