Human formyl peptide receptor 1 C32T SNP interacts with age and is associated with blood pressure levels.
Fiche publication
Date publication
janvier 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VISVIKIS Sophie
Tous les auteurs :
El Shamieh S, Herbeth B, Azimi-Nezhad M, Benachour H, Masson C, Visvikis-Siest S
Lien Pubmed
Résumé
BACKGROUND: Human formyl peptide receptor 1 (FPR1) mediates inflammatory responses, recognized as important participants in the physiopathology of hypertension. Similarly, FPR1 C32T SNP is associated with inflammation and BP related pathways. Therefore, the relationship between FPR1 C32T SNP, BP and hypertension needs to be investigated. METHOD: 1012 French middle-aged adults including 491 healthy individuals (5 years follow-up, T(+0) and T(+5)) and 521 hypertensive individuals were PCR-RFLP genotyped for FPR1 C32T SNP (rs5030878). RESULTS: At entrance, there was no significant association between FPR1 C32T SNP and blood pressure (BP) in healthy individuals. However, 5 years later, significant associations were found for DBP, SBP (p
Référence
Clin Chim Acta. 2012 Jan 18;413(1-2):34-8