Triterpenoid saponins from Hydrocotyle bonariensis Lam.
Fiche publication
Date publication
janvier 2012
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DUCHAMP Olivier
Tous les auteurs :
Tabopda TK, Mitaine-Offer AC, Miyamoto T, Tanaka C, Mirjolet JF, Duchamp O, Ngadjui BT, Lacaille-Dubois MA
Lien Pubmed
Résumé
Phytochemical investigation of the under-ground parts of Hydrocotyle bonariensis led to the isolation of five oleanane-type triterpenoid saponins, 3-O-{beta-D-glucopyranosyl-(1 --> 2)-[alpha-L-arabinopyranosyl-(1 --> 3)]-beta-D-glucuronopyranosyl}-21-O-(2-methylbutyroyl)-22-O-acetyl-R(1)-barrigeno l, 3-O-{beta-D-glucopyranosyl-(1 --> 2)-[alpha-L-arabinopyranosyl-(1 --> 3)]-beta-D-glucuronopyranosyl}-21-O-(2-methylbutyroyl)-28-O-acetyl-R(1)-barrigeno l, 3-O-{beta-D-glucopyranosyl-(1 --> 2)-[alpha-L-arabinopyranosyl-(1 --> 3)]-beta-D-glucuronopyranosyl}-21-O-acetyl-R(1)-barrigenol, 3-O-{beta-D-glucopyranosyl-(1 --> 2)-[alpha-L-arabinopyranosyl-(1 --> 3)]-beta-D-glucuronopyranosyl}-R(1)-barrigenol, and 3-O-{beta-D-glucopyranosyl-(1 --> 2)-[alpha-L-arabinopyranosyl-(1 --> 3)]-beta-D-glucuronopyranosyl}-22-O-(2-methylbutyroyl)-A(1)-barrigenol, together with the known saniculoside-R1. Their structures were established by 2D NMR techniques and mass spectrometry. Six compounds were evaluated against two human colon cancer cell lines, HCT 116 and HT-29. Two compounds showed weak cytotoxicity with IC(50) 24.1 and 24.0, 83.0 and 83.6 muM against HT-29 and HCT 116, respectively.
Référence
Phytochemistry. 2012 Jan;73(1):142-7