Glaucasides A-C, three saikosaponins from Atriplex glauca L. var. ifiniensis (Caball) Maire.
Fiche publication
Date publication
février 2011
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DUCHAMP Olivier
Tous les auteurs :
Jabrane A, Ben Jannet H, Miyamoto T, Tanaka C, Mirjolet JF, Duchamp O, Harzallah-Skhiri F, Lacaille-Dubois MA
Lien Pubmed
Résumé
From the roots of Atriplex glauca L. var. ifiniensis (Caball) Maire (syn. of Atriplex parvifolia Lowe var. genuina Maire), three new saikosaponins designated as glaucasides A-C (1-3) were isolated together with the known 3-O-beta-D-glucopyranosyl-(1 --> 2)-beta-D-galactopyranosyl-saikogenin F (4). The structures of the new compounds were elucidated by extensive analysis of one-dimensional and two-dimensional NMR spectroscopy, FABMS, HR-ESIMS and chemical evidence as 13beta,28-epoxy-16beta,21beta-dihydroxyolean-11-en-3beta-yl O-beta-D-[2-O-sulfate]-glucopyranosyl-(1 --> 2)-alpha-L-arabinopyranoside (1), 13beta,28-epoxy-16beta,21beta-dihydroxyolean-11-en-3beta-yl O-beta-D-[2-O-sulfate]-glucopyranosyl-(1 --> 2)-alpha-L-arabinopyranosyl 21-O-{4-(secbutylamido)-butanoyl ester} (2) and 3-O-beta-D-glucopyranosyl-(1 --> 2)-beta-D-galactopyranosyl saikogenin G (3). The cytotoxic activities of these compounds were evaluated against the HT-29 and HCT 116 human colon cancer cell lines.
Référence
Magn Reson Chem. 2011 Feb;49(2):83-9