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Integrase-LEDGF/p75 complex triggers the formation of biomolecular condensates that modulate HIV-1 integration efficiency in vitro.

Batisse C, Lapaillerie D, Humbert N, Real E, Zhu R, Mély Y, Parissi V, Ruff M, Batisse J

J Biol Chem. 2024 05 16;:107374

The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton.

Rivera Alvarez J, Asselin L, Tilly P, Benoit R, Batisse C, Richert L, Batisse J, Morlet B, Levet F, Schwaller N, Mély Y, Ruff M, Reymann AC, Godin JD

Cell Rep. 2023 07 6;42(7):112744

Modulation of the functional interfaces between retroviral intasomes and the human nucleosome.

Mauro E, Lapaillerie D, Tumiotto C, Charlier C, Martins F, Sousa SF, Métifiot M, Weigel P, Yamatsugu K, Kanai M, Munier-Lehmann H, Richetta C, Maisch M, Dutrieux J, Batisse J, Ruff M, Delelis O, Lesbats P, Parissi V

mBio. 2023 06 29;:e0108323

Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.

Bonnard D, Le Rouzic E, Singer MR, Yu Z, Le Strat F, Batisse C, Batisse J, Amadori C, Chasset S, Pye VE, Emiliani S, Ledoussal B, Ruff M, Moreau F, Cherepanov P, Benarous R

Antimicrob Agents Chemother. 2023 06 13;:e0046223

Inhibitors of UHRF1 base flipping activity showing cytotoxicity against cancer cells.

Ciaco S, Mazzoleni V, Javed A, Eiler S, Ruff M, Mousli M, Mori M, Mély Y

Bioorg Chem. 2023 05 22;137:106616

Efficient production of protein complexes in mammalian cells using a poxvirus vector.

Drillien R, Pradeau-Aubreton K, Batisse J, Mezher J, Schenckbecher E, Marguin J, Ennifar E, Ruff M

PLoS One. 2022 12 15;17(12):e0279038

The HIV-1 Integrase C-Terminal Domain Induces TAR RNA Structural Changes Promoting Tat Binding.

Rocchi C, Louvat C, Miele AE, Batisse J, Guillon C, Ballut L, Lener D, Negroni M, Ruff M, Gouet P, Fiorini F

Int J Mol Sci. 2022 11 8;23(22):

Thienoguanosine brightness in DNA duplexes is governed by the localization of its ππ* excitation in the lowest energy absorption band.

Ciaco S, Gavvala K, Greiner V, Mazzoleni V, Didier P, Ruff M, Martinez-Fernandez L, Improta R, Mely Y

Methods Appl Fluoresc. 2022 Apr 26;:

NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases.

Kanja M, Cappy P, Levy N, Oladosu O, Schmidt S, Rossolillo P, Winter F, Gasser R, Moog C, Ruff M, Negroni M, Lener D

J. Virol.. 2020 Jul 29;:

HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates.

Bonam SR, Ruff M, Muller S

Cells. 2019 Aug 7;8(8):

A molecular tool targeting the base flipping activity of human UHRF1.

Zaayter L, Mori M, Ahmad T, Ashraf W, Boudier C, Kilin V, Gavvala K, Richert L, Eiler S, Ruff M, Botta M, Bronner C, Mousli M, Mely Y

Chemistry. 2019 Jul 19;:

Structural basis for E. coli Penicillin Binding Protein (PBP) 2 inhibition, a platform for drug design.

Levy N, Bruneau JM, Le Rouzic E, Bonnard D, Le Strat F, Caravano A, Chevreuil F, Barbion J, Chasset S, Ledoussal B, Moreau F, Ruff M

J. Med. Chem.. 2019 Apr 17;:

Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase.

Mauro E, Lesbats P, Lapaillerie D, Chaignepain S, Maillot, Oladosu O, Robert X, Fiorini F, Kieffer B, Bouaziz S, Gouet P, Ruff M, Parissi V

Nucleic Acids Res.. 2019 02 15;:

Publisher Correction: Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain.

Bedez C, Lotz C, Batisse C, Broeck AV, Stote RH, Howard E, Pradeau-Aubreton K, Ruff M, Lamour V

Sci Rep. 2018 Jul 10;8(1):10673

Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain.

Bedez C, Lotz C, Batisse C, Broeck AV, Stote RH, Howard E, Pradeau-Aubreton K, Ruff M, Lamour V

Sci Rep. 2018 Jun 18;8(1):9272

Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.

Bonnard D, Le Rouzic E, Eiler S, Amadori C, Orlov I, Bruneau JM, Brias J, Barbion J, Chevreuil F, Spehner D, Chasset S, Ledoussal B, Moreau F, Saïb A, Klaholz BP, Emiliani S, Ruff M, Zamborlini A, Benarous R

J. Biol. Chem.. 2018 Apr 20;293(16):6172-6186

Unstable Protein Purification Through the Formation of Stable Complexes.

Eiler S, Levy N, Maillot B, Batisse J, Aubreton KP, Oladosu O, Ruff M

Methods Mol. Biol.. 2018 ;1764:315-328

Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails.

Benleulmi MS, Matysiak J, Robert X, Miskey C, Mauro E, Lapaillerie D, Lesbats P, Chaignepain S, Henriquez DR, Calmels C, Oladosu O, Thierry E, Leon O, Lavigne M, Andreola ML, Delelis O, Ivics Z, Ruff M, Gouet P, Parissi V

Retrovirology. 2017 Nov 28;14(1):54

The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.

Amadori C, van der Velden YU, Bonnard D, Orlov I, van Bel N, Le Rouzic E, Miralles L, Brias J, Chevreuil F, Spehner D, Chasset S, Ledoussal B, Mayr L, Moreau F, García F, Gatell J, Zamborlini A, Emiliani S, Ruff M, Klaholz BP, Moog C, Berkhout B, Plana M, Benarous R

Retrovirology. 2017 Nov 9;14(1):50

Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration.

Matysiak J, Lesbats P, Mauro E, Lapaillerie D, Dupuy JW, Lopez AP, Benleulmi MS, Calmels C, Andreola ML, Ruff M, Llano M, Delelis O, Lavigne M, Parissi V

Retrovirology. 2017 Jul;14(1):39

Dynamics of Methylated Cytosine Flipping by UHRF1.

Kilin V, Gavvala K, Barthes NP, Michel BY, Shin D, Boudier C, Mauffret O, Yashchuk V, Mousli M, Ruff M, Granger F, Eiler S, Bronner C, Tor Y, Burger A, Mély Y

J. Am. Chem. Soc.. 2017 Feb;139(6):2520-2528

DNA minicircles clarify the specific role of DNA structure on retroviral integration.

Pasi M, Mornico D, Volant S, Juchet A, Batisse J, Bouchier C, Parissi V, Ruff M, Lavery R, Lavigne M

Nucleic Acids Res.. 2016 Sep;44(16):7830-47

Production of unstable proteins through the formation of stable core complexes.

Levy N, Eiler S, Pradeau-Aubreton K, Maillot B, Stricher F, Ruff M

Nat Commun. 2016 Mar;7:10932

Site-Selective Monitoring of the Interaction of the SRA Domain of UHRF1 with Target DNA Sequences Labeled with 2-Aminopurine.

Greiner VJ, Kovalenko L, Humbert N, Richert L, Birck C, Ruff M, Zaporozhets OA, Dhe-Paganon S, Bronner C, Mely Y

Biochemistry. 2015 Sep 23.

Intasome architecture and chromatin density modulate retroviral integration into nucleosome.

Benleulmi MS, Matysiak J, Henriquez DR, Vaillant C, Lesbats P, Calmels C, Naughtin M, Leon O, Skalka AM, Ruff M, Lavigne M, Andreola ML, Parissi V

Retrovirology. 2015 Feb;12:13

DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase Selectivity.

Naughtin M, Haftek-Terreau Z, Xavier J, Meyer S, Silvain M, Jaszczyszyn Y, Levy N, Miele V, Benleulmi MS, Ruff M, Parissi V, Vaillant C, Lavigne M

PLoS One. 2015 Jun 15;10(6):e0129427

Functional relationship between matrix metalloproteinase-11 and matrix metalloproteinase-14.

Buache E, Thai R, Wendling C, Alpy F, Page A, Chenard MP, Dive V, Ruff M, Dejaegere A, Tomasetto C, Rio MC

Cancer Med. 2014 Oct;3(5):1197-210

HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.

Stricher F, Macri C, Ruff M, Muller S

Autophagy. 2013 Dec;9(12):1937-54

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.

Le Rouzic E, Bonnard D, Chasset S, Bruneau JM, Chevreuil F, Le Strat F, Nguyen J, Beauvoir R, Amadori C, Brias J, Vomscheid S, Eiler S, Levy N, Delelis O, Deprez E, Saib A, Zamborlini A, Emiliani S, Ruff M, Ledoussal B, Moreau F, Benarous R

Retrovirology. 2013 Nov 21;10:144

Expression of functional full-length hSRC-1 in eukaryotic cells using modified vaccinia virus Ankara and baculovirus.

Osz J, Pradeau-Aubreton K, Drillien R, Troffer-Charlier N, Kolb-Cheynel I, Poterszman A, Ruff M, Moras D, Rochel N

Anal Biochem. 2012 Jul 15;426(2):106-8

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.

Osz J, Brelivet Y, Peluso-Iltis C, Cura V, Eiler S, Ruff M, Bourguet W, Rochel N, Moras D

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):E588-94

Using Vaccinia's innate ability to introduce DNA into mammalian cells for production of recombinant proteins.

Jester BC, Drillien R, Ruff M, Florentz C

J Biotechnol. 2011 Dec 10;156(3):211-3

Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import.

Cribier A, Segeral E, Delelis O, Parissi V, Simon A, Ruff M, Benarous R, Emiliani S

Retrovirology. 2011 Dec 16;8:104.

Vectors for recombinational cloning and gene expression in mammalian cells using modified vaccinia virus Ankara.

Pradeau-Aubreton K, Ruff M, Garnier JM, Schultz P, Drillien R

Anal Biochem. 2010 Sep 1;404(1):103-5

Towards high-throughput identification of endocrine disrupting compounds with mass spectrometry.

Bovet C, Plet B, Ruff M, Eiler S, Granger F, Panagiotidis A, Wenzel R, Nazabal A, Moras D, Zenobi R

Toxicol In Vitro. 2009 Jun;23(4):704-9

Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor.

Michel F, Crucifix C, Granger F, Eiler S, Mouscadet JF, Korolev S, Agapkina J, Ziganshin R, Gottikh M, Nazabal A, Emiliani S, Benarous R, Moras D, Schultz P, Ruff M

EMBO J. 2009 Apr 8;28(7):980-91