Détail d'une personne de l'annuaire - fr | Cancéropôle Est, la recherche innovante dans la lutte contre le cancer

Fluorinated apelin-13 mediates neuroprotective effects in multiple sclerosis models.

Birmpili D, Charmarké-Askar I, Spenlé C, Riché S, Pham-Van LD, Kuntzel T, Xhurxhi T, Riou A, Bonnet D, Bagnard D

Neurobiol Dis. 2024 06 4;198:106552

Alared: Solvatochromic and Fluorogenic Red Amino Acid for Ratiometric Live-cell Imaging of Bioactive Peptides.

Mirloup A, Berthomé Y, Riché S, Wagner P, Hanser F, Laurent A, Iturrioz X, Llorens-Cortes C, Karpenko J, Bonnet D

Chemistry. 2024 04 20;:e202401296

Rapid and Highly Selective Fluorescent Labeling of Peptides via a Thia-Diels-Alder Cycloaddition: Application to Apelin.

Maujean T, Wagner P, Valencia C, Riché S, Iturrioz X, Villa P, Girard N, Karpenko J, Gulea M, Bonnet D

Bioconjug Chem. 2022 12 19;:

Hetero-Diels-Alder click reaction of dithioesters for a catalyst-free indirect F-radiolabelling of peptides.

Maujean T, Marchand P, Wagner P, Riché S, Boisson F, Girard N, Bonnet D, Gulea M

Chem Commun (Camb). 2022 09 15;:

Functional Rescue of a Nephrogenic Diabetes Insipidus Causing Mutation in the V2 Vasopressin Receptor by Specific Antagonist and Agonist Pharmacochaperones.

Szalai L, Sziráki A, Erdélyi LS, Kovács KB, Tóth M, Tóth AD, Turu G, Bonnet D, Mouillac B, Hunyady L, Balla A

Front Pharmacol. 2022 ;13:811836

Nile Red-Based GPCR Ligands as Ultrasensitive Probes of the Local Lipid Microenvironment of the Receptor.

Hanser F, Marsol C, Valencia C, Villa P, Klymchenko AS, Bonnet D, Karpenko J

ACS Chem Biol. 2021 Mar 18;:

A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia.

Flahault A, Girault-Sotias PE, Keck M, Alvear-Perez R, De Mota N, Estéoulle L, Ramanoudjame SM, Iturrioz X, Bonnet D, Llorens-Cortes C

Nat Commun. 2021 01 12;12(1):305

A Selective Neutraligand for CXCL12/SDF-1α With Beneficial Regulatory Functions in MRL/Lpr Lupus Prone Mice.

Schall N, Daubeuf F, Marsol C, Gizzi P, Frossard N, Bonnet D, Galzi JL, Muller S

Front Pharmacol. 2021 ;12:752194

LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats a NO Synthase-dependent Mechanism.

Flahault A, Keck M, Girault-Sotias PE, Esteoulle L, De Mota N, Bonnet D, Llorens-Cortes C

Front Pharmacol. 2021 ;12:715095

Three cheers for nitrogen: aza-DKPs, the aza analogues of 2,5-diketopiperazines.

Maujean T, Girard N, Ganesan A, Gulea M, Bonnet D

RSC Adv. 2020 Nov 27;10(71):43358-43370

Self-organization properties of a GPCR binding peptide incorporating fluorinated tail studied by fluorine NMR.

Jourdain de Muizon C, Ramanoudjame S, Esteoulle L, Ling C, Brou G, Anton N, Vandamme T, Delsuc MA, Bonnet D, Kieffer B

Chembiochem. 2020 Sep 28;:

A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice.

Esteoulle L, Daubeuf F, Collot M, Riché S, Durroux T, Brasse D, Marchand P, Karpenko IA, Klymchenko AS, Bonnet D

Chem Sci. 2020 Jul 14;11(26):6824-6829

Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.

Fellous TG, Redpath AN, Fleischer MM, Gandhi S, Hartner SE, Newton MD, François M, Wong SP, Gowers KHC, Fahs AM, Possley DR, Bonnet D, Urquhart P, Nicolaou A, Baker KC, Rankin SM

NPJ Regen Med. 2020 Feb 21;5(1):3

Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.

Fellous TG, Redpath AN, Fleischer MM, Gandhi S, Hartner SE, Newton MD, François M, Wong SP, Gowers KHC, Fahs AM, Possley DR, Bonnet D, Urquhart P, Nicolaou A, Baker KC, Rankin SM

NPJ Regen Med. 2020 ;5:3

Neutralization of CXCL12 attenuates established pulmonary hypertension in rats.

Bordenave J, Thuillet R, Tu L, Phan C, Cumont A, Marsol C, Huertas A, Savale L, Hibert M, Galzi JL, Bonnet D, Humbert M, Frossard N, Guignabert C

Cardiovasc. Res.. 2019 Jun 7;:

Chemoselective Acylation of Hydrazinopeptides to Access Fluorescent Probes for Time-Resolved FRET Assays on GPCRs.

Ramanoudjame SM, Esteoulle L, Riché S, Margathe JF, Durroux T, Karpenko IA, Bonnet D

Methods Mol. Biol.. 2019 ;1947:137-147

Time-Resolved FRET-Based Assays to Characterize G Protein-Coupled Receptor Hetero-oligomer Pharmacology.

Heuninck J, Hounsou C, Dupuis E, Trinquet E, Mouillac B, Pin JP, Bonnet D, Durroux T

Methods Mol. Biol.. 2019 ;1947:151-168

Versatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines.

Péron F, Riché S, Lesur B, Hibert M, Breton P, Fourquez JM, Girard N, Bonnet D

ACS Omega. 2018 Nov 30;3(11):15182-15192

LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism.

Frantz MC, Pellissier LP, Pflimlin E, Loison S, Gandía J, Marsol C, Durroux T, Mouillac B, Becker JAJ, Le Merrer J, Valencia C, Villa P, Bonnet D, Hibert M

J. Med. Chem.. 2018 Sep 24;:

Two distinct CXCR4 antagonists mobilize progenitor cells in mice by different mechanisms.

Redpath AN, François M, Wong SP, Bonnet D, Rankin SM

Blood Adv. 2017 Oct 10;1(22):1934-1943

A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor.

Valencia C, Dujet C, Margathe JF, Iturrioz X, Roux T, Trinquet E, Villa P, Hibert M, Dupuis E, Llorens-Cortes C, Bonnet D

ChemMedChem. 2017 Apr;:

Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines.

Regenass P, Bosc D, Riché S, Gizzi P, Hibert M, Karmazin L, Ganesan A, Bonnet D

J. Org. Chem.. 2017 Mar;82(6):3239-3244

Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects.

Gerbier R, Alvear-Perez R, Margathe JF, Flahault A, Couvineau P, Gao J, De Mota N, Dabire H, Li B, Ceraudo E, Hus-Citharel A, Esteoulle L, Bisoo C, Hibert M, Berdeaux A, Iturrioz X, Bonnet D, Llorens-Cortes C

FASEB J.. 2017 Feb;31(2):687-700

Decreased Migration of Dendritic Cells into the Jugular-Nodose Ganglia by the CXCL12 Neutraligand Chalcone 4 in Ovalbumin-Sensitized Asthmatic Mice.

Heck S, Daubeuf F, Le DD, Sester M, Bonnet D, Bals R, Frossard N, Dinh QT

Neuroimmunomodulation. 2017 ;24(6):331-340

A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis.

Regenass P, Riché S, Péron F, Rognan D, Hibert M, Girard N, Bonnet D

Org. Biomol. Chem.. 2016 Sep;14(37):8859-8863

Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions.

Karpenko IA, Niko Y, Yakubovskyi VP, Gerasov AO, Bonnet D, Kovtun YP, Klymchenko AS

J Mater Chem C Mater. 2016 Apr 14;4(14):3002-3009

Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging.

Margathe JF, Iturrioz X, Regenass P, Karpenko IA, Humbert N, de Rocquigny H, Hibert M, Llorens-Cortes C, Bonnet D

Chemistry. 2016 Jan;22(4):1399-405

Increasing cellular immunogenicity to peptide-based vaccine candidates using a fluorocarbon antigen delivery system.

Francis JN, Thaburet JF, Bonnet D, Sizer PJ, Brown CB, Georges B

Vaccine. 2015 Feb 18;33(8):1071-6

Small neutralizing molecules to inhibit actions of the chemokine CXCL12.

Hachet-Haas M, Balabanian K, Rohmer F, Pons F, Franchet C, Lecat S, Chow KY, Dagher R, Gizzi P, Didier B, Lagane B, Kellenberger E, Bonnet D, Baleux F, Haiech J, Parmentier M, Frossard N, Arenzana-Seisdedos F, Hibert M, Galzi JL

J Biol Chem. 2008 Aug 22;283(34):23189-99

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Publications

Fluorinated apelin-13 mediates neuroprotective effects in multiple sclerosis models.

Alared: Solvatochromic and Fluorogenic Red Amino Acid for Ratiometric Live-cell Imaging of Bioactive Peptides.

Rapid and Highly Selective Fluorescent Labeling of Peptides via a Thia-Diels-Alder Cycloaddition: Application to Apelin.

Hetero-Diels-Alder click reaction of dithioesters for a catalyst-free indirect F-radiolabelling of peptides.

Functional Rescue of a Nephrogenic Diabetes Insipidus Causing Mutation in the V2 Vasopressin Receptor by Specific Antagonist and Agonist Pharmacochaperones.

Nile Red-Based GPCR Ligands as Ultrasensitive Probes of the Local Lipid Microenvironment of the Receptor.

A metabolically stable apelin-17 analog decreases AVP-induced antidiuresis and improves hyponatremia.

A Selective Neutraligand for CXCL12/SDF-1α With Beneficial Regulatory Functions in MRL/Lpr Lupus Prone Mice.

LIT01-196, a Metabolically Stable Apelin-17 Analog, Normalizes Blood Pressure in Hypertensive DOCA-Salt Rats a NO Synthase-dependent Mechanism.

Three cheers for nitrogen: aza-DKPs, the aza analogues of 2,5-diketopiperazines.

Self-organization properties of a GPCR binding peptide incorporating fluorinated tail studied by fluorine NMR.

A near-infrared fluorogenic dimer enables background-free imaging of endogenous GPCRs in living mice.

Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.

Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery.

Neutralization of CXCL12 attenuates established pulmonary hypertension in rats.

Chemoselective Acylation of Hydrazinopeptides to Access Fluorescent Probes for Time-Resolved FRET Assays on GPCRs.

Time-Resolved FRET-Based Assays to Characterize G Protein-Coupled Receptor Hetero-oligomer Pharmacology.

Versatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines.

LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism.

Two distinct CXCR4 antagonists mobilize progenitor cells in mice by different mechanisms.

A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor.

Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines.

Development of original metabolically stable apelin-17 analogs with diuretic and cardiovascular effects.

Decreased Migration of Dendritic Cells into the Jugular-Nodose Ganglia by the CXCL12 Neutraligand Chalcone 4 in Ovalbumin-Sensitized Asthmatic Mice.

A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis.

Push-pull dioxaborine as fluorescent molecular rotor: far-red fluorogenic probe for ligand-receptor interactions.

Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging.

Increasing cellular immunogenicity to peptide-based vaccine candidates using a fluorocarbon antigen delivery system.

Small neutralizing molecules to inhibit actions of the chemokine CXCL12.