Détail d'une personne de l'annuaire - fr | Cancéropôle Est, la recherche innovante dans la lutte contre le cancer

Protocol to generate, purify, and analyze antibody-oligonucleotide conjugates from off-the-shelf antibodies.

Rady T, Lehot V, Most J, Erb S, Cianferani S, Chaubet G, Basse N, Wagner A

STAR Protoc. 2024 09 28;5(4):103329

Retinoids Molecular Probes by Late-stage Azide Insertion - Functional Tools to Decrypt Retinoid Metabolism.

Coulleray J, Kindler A, Rima M, Cahuzac H, Rochel N, Chaubet G, Krezel W, Wagner A

Chembiochem. 2024 08 2;:e202300689

Chemical Production of Cytotoxic Bispecific Antibodies Using the Ugi Multicomponent Reaction.

Vaur V, Koutsopetras I, Erb S, Jackowska B, Benazza R, Cahuzac H, Detappe A, Hernandez-Alba O, Cianférani S, Scott CJ, Chaubet G

Chembiochem. 2024 05 7;:e202400170

Targeted delivery of immune-stimulating bispecific RNA, inducing apoptosis and anti-tumor immunity in cancer cells.

Rady T, Erb S, Deddouche-Grass S, Morales R, Chaubet G, Cianférani S, Basse N, Wagner A

iScience. 2024 03 15;27(3):109068

SEC-MS in denaturing conditions (dSEC-MS) for in-depth analysis of rebridged monoclonal antibody-based formats.

Benazza R, Koutsopetras I, Vaur V, Chaubet G, Hernandez-Alba O, Cianférani S

Talanta. 2024 01 29;272:125727

Site-Selective Protein Conjugation by a Multicomponent Ugi Reaction.

Koutsopetras I, Vaur V, Benazza R, Diemer H, Sornay C, Ersoy Y, Rochet L, Longo C, Hernandez-Alba O, Erb S, Detappe A, Skerra A, Wagner A, Cianferani S, Chaubet G

Chemistry. 2023 12 5;:e202303242

Reinvestigation of the Automated Synthesis of Stoichiometrically Conjugated Antibodies to Access High Molecular Weight Payloads and Multiplexed Conjugation via an In-Solution Trans-Tagging Process.

Lehot V, Lidický O, Most J, Erb S, Dovgan I, Osypenko A, Koniev O, Kolodych S, Kotrchová L, Chaubet G, Cianférani S, Etrych T, Wagner A

ACS Omega. 2023 10 31;8(43):40508-40516

Cysteine-Cysteine Cross-Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine-Electrophilic Reagent.

Koutsopetras I, Mishra AK, Benazza R, Hernandez-Alba O, Cianférani S, Chaubet G, Nicolai S, Waser J

Chemistry. 2023 09 15;:e202302689

Microfluidic Droplet Stabilization via SPAAC Promoted Antibody Conjugation at the Water/Oil Interface.

Dufossez R, Krafft MP, Ursuegui S, Mosser M, Mouftakhir S, Pernod K, Chaubet G, Ryckelynck M, Wagner A

ACS Appl Mater Interfaces. 2023 09 13;:

Targeted Anticancer Agent with Original Mode of Action Prepared by Supramolecular Assembly of Antibody Oligonucleotide Conjugates and Cationic Nanoparticles.

Lehot V, Neuberg P, Ripoll M, Daubeuf F, Erb S, Dovgan I, Ursuegui S, Cianférani S, Kichler A, Chaubet G, Wagner A

Pharmaceutics. 2023 06 2;15(6):

Droplet Surface Immunoassay by Relocation (D-SIRe) for High-Throughput Analysis of Cytosolic Proteins at the Single-Cell Level.

Dufossez R, Ursuegui S, Baudrey S, Pernod K, Mouftakhir S, Oulad-Abdelghani M, Mosser M, Chaubet G, Ryckelynck M, Wagner A

Anal Chem. 2023 02 23;:

A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity.

Rady T, Turelli L, Nothisen M, Tobaldi E, Erb S, Thoreau F, Hernandez-Alba O, Cianferani S, Daubeuf F, Wagner A, Chaubet G

Bioconjug Chem. 2022 09 15;:

Arginine-selective bioconjugation with 4-azidophenyl glyoxal: application to the single and dual functionalisation of native antibodies.

Dovgan I, Erb S, Hessmann S, Ursuegui S, Michel C, Muller C, Chaubet G, Cianférani S, Wagner A

Org. Biomol. Chem.. 2018 Feb 21;16(8):1305-1311

Total Synthesis of the Schisandraceae Nortriterpenoid Rubriflordilactone A.

Chaubet G, Goh SS, Mohammad M, Gockel B, Cordonnier MA, Baars H, Phillips AW, Anderson EA

Chemistry. 2017 10 9;23(56):14080-14089

Total Synthesis of (+)-Rubriflordilactone A.

Goh SS, Chaubet G, Gockel B, Cordonnier MC, Baars H, Phillips AW, Anderson EA

Angew Chem Int Ed Engl. 2015 10 19;54(43):12618-21

Dr CHAUBET Guilhem

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Publications

Protocol to generate, purify, and analyze antibody-oligonucleotide conjugates from off-the-shelf antibodies.

Retinoids Molecular Probes by Late-stage Azide Insertion - Functional Tools to Decrypt Retinoid Metabolism.

Chemical Production of Cytotoxic Bispecific Antibodies Using the Ugi Multicomponent Reaction.

Targeted delivery of immune-stimulating bispecific RNA, inducing apoptosis and anti-tumor immunity in cancer cells.

SEC-MS in denaturing conditions (dSEC-MS) for in-depth analysis of rebridged monoclonal antibody-based formats.

Site-Selective Protein Conjugation by a Multicomponent Ugi Reaction.

Reinvestigation of the Automated Synthesis of Stoichiometrically Conjugated Antibodies to Access High Molecular Weight Payloads and Multiplexed Conjugation via an In-Solution Trans-Tagging Process.

Cysteine-Cysteine Cross-Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine-Electrophilic Reagent.

Microfluidic Droplet Stabilization via SPAAC Promoted Antibody Conjugation at the Water/Oil Interface.

Targeted Anticancer Agent with Original Mode of Action Prepared by Supramolecular Assembly of Antibody Oligonucleotide Conjugates and Cationic Nanoparticles.

Droplet Surface Immunoassay by Relocation (D-SIRe) for High-Throughput Analysis of Cytosolic Proteins at the Single-Cell Level.

A Novel Family of Acid-Cleavable Linker Based on Cyclic Acetal Motifs for the Production of Antibody-Drug Conjugates with High Potency and Selectivity.

An overview of chemo- and site-selectivity aspects in the chemical conjugation of proteins.

Bicyclo[6.1.0]nonyne carboxylic acid for the production of stable molecular probes.

Plasma induced acceleration and selectivity in strain-promoted azide-alkyne cycloadditions.

Non-specific interactions of antibody-oligonucleotide conjugates with living cells.

Manniindole, an indole derivative from the roots of and combined antischistosomal and enzymatic activities.

Investigating Ugi / Passerini multicomponent reactions for the Site-Selective Conjugation of Native Trastuzumab.

Ethynylation of Cysteines from Peptides to Proteins in Living Cells.

Recent, non-classical, approaches to antibody lysine modification.

Arginine-selective bioconjugation with 4-azidophenyl glyoxal: application to the single and dual functionalisation of native antibodies.

Total Synthesis of the Schisandraceae Nortriterpenoid Rubriflordilactone A.

Total Synthesis of (+)-Rubriflordilactone A.